Fig. 9

The communication signals differed between glycan-HCC and lipid-HCC patients. Unified manifold approximation and projection (UMAP) representation of single-cell gene expression in different patients (a), cell types (b) and metabolic subtypes (c). Umap plots were generated by using “Seurat” software. d Heatmap shows differential interaction strength among different cell types. The communication proportions (e) and levels (f) of signals differed between glycan-HCC and lipid-HCC patients. Figure were generated by using “CellChat” package in R softeare