Fig. 5

Transcriptomic characterization of metabolic subtypes. Volcano plots showed differentially expressed genes between glycan-HCCs and lipid-HCCs in TCGA (a), ICGC (b), CPTAC (c) and in-house cohort (d). Gene set enrichment analysis showed pathways enriched in glycan-HCC in TCGA (e), ICGC (f), CPTAC (g) and in-house cohort (h). “Cell cycle” and “Ribosome” pathways were noticed up-regulated in glycan-HCCs in all four cohorts