Fig. 5

Intercellular communication and signaling networks in bone tumor microenvironment. A Heatmap of outgoing and incoming signaling patterns for each immune cell cluster. B Bar plots summarizing the overall communication strength of major pathways across immune cell clusters. C Scatter plot showing the relative contribution of different immune cell clusters to shaping the immune microenvironment (outgoing signaling strength) and receiving environmental signals (incoming signaling strength). D Circle plots displaying the detailed intercellular communication network for FN1 signaling pathways. E Dot plot illustrating the specific interaction mechanisms within the FN1 signaling pathway