Fig. 2
Immune cell composition and functional correlation in bone tumor samples. A Bar plot showing the distribution of immune cell clusters across individual tumor samples. B Cluster dendrogram displaying the similarity between tumor samples. Based on immune cell composition, samples are categorized into three groups. C Boxplots grouped by tumor type (OS, ES, and GCTB) showing the distribution of immune cell clusters with significant differences. D Boxplots grouped by the immune classification identified in B. E Matrix plot showing Mantel’s test results for pairwise correlation between immune cell clusters based on gene expression profiles. The correlation strength (r value) and statistical significance (P-value) are represented by color intensity. F Scatter plots showing the correlation of C06_Macrophage_APOE with C09_Tnaive_TCF7 and C11_NK_KLRD1. The X-axis represents the percentage of C06_Macrophage_APOE, while the Y-axis shows the percentage of the respective clusters