Fig. 7
YTHDF1 facilitates ANXA4 translation through m6A modification. A-B QPCR was used to explore the interaction between BAIAP2L2 and ANXA4. D, E QPCR and western blot were used to explore the regulation effect of YTHDF1 on ANXA4. F CCK-8 were used to explore the counteraction of knockdown of ANXA4 in MKN45 cells to the effect of EVs isolated from YTHDF1 overexpression MKN45/DDP. G CCK-8 were used to explore the counteraction of knockdown of ANXA4 in YTHDF1 overexpression MKN45/DDP cells to the effect of MKN45. H Flow diagram of Flow diagram of Subcutaneous tumor model. I The subcutaneous tumors from the BALB/c Nude mice injected MKN45 sensitive cells, with DDP treatment (DDP 5 mg/kg once per week), with 20 μg of different EVs (resuspended in 40 μL of PBS) injected through the caudal vein as once per week. J Volume of subcutaneous tumors. Data on subcataneous tumor volume were analyzed by 2-way ANOVA. J Flow diagram of the subcutaneous tumor xenograft experiment in BALB/c Nude mice. K Mechanism diagram. The figures and graphical elements were created and compiled using Figdraw (https://www.figdraw.com/)