Fig. 3

Chemotherapy resistant GC cells transmit chemotherapy resistance to sensitive cells through EVs. A GSEA plot for the mechanism of cisplatin recurrence in gastric cancer that BAIAP2L2 is most likely involved. B Representative transmission electron microscope image (scale, 100 nm) of EVs derived from MKN45/DDP cells. C Nanoparticle Tracking Analysis (NTA) were performed to show purified EV size (nm). D Exosomal markers (HSP70, TSG101, CD9 and CD63) in MKN45/DDP cell proteins and corresponding EVs were analyzed by Western Blot. E Flow diagram of EV labeling and co-culture. F Immunofluorescence (IF) showed that EVs derived from MKN45/DDP stained with PKH67 fused into sensitive MKN45 cells. Scale bars were 20 μm. G CCK-8 were used to explore the effect of EVs_MKN45/DDP. H Mechanism overview diagram. The figures and graphical elements were created and compiled using Figdraw (https://www.figdraw.com/)