Fig. 2

Pharmacological inhibition of SET7 catalytic activity reduces the development of atherosclerotic lesions in ApoE-/- mice. a, Schematic overview of the general experimental strategy. b, Quantification of atherosclerotic lesions in aortic root. c, Representative images depicting H&E-stained aortic root atherosclerotic plaques. d, Quantification of en face ORO-positive areas in the aorta of ApoE-/- mice. e, En face examination of atherosclerotic lesion development along the aorta of mice. Images were taken in the absence (-) ore presence (+) of ORO lipid staining reagent. f, Assessment of plasma total cholesterol, triglycerides and body weight of mice at the moment of sacrifice. n = 5–12, ** p < 0.01, *** p < 0.001. p-values were considered in relation to ND + Veh condition. # p < 0.05. p-values were considered in relation to HD + Veh condition