Fig. 7

External dataset validation of the effect of RPCD Risk score on AD prediction. A ROC curves of RPCD Risk score and key proteins in MSBB parahippocampal gyrus proteomic data. B ROC curves of RPCD Risk score in MSBB frontal pole, inferior frontal gyrus and superior temporal gyrus RNA-Seq data. C RPCD Risk score ROC curves in GEO hippocampus, internal olfactory cortex, temporal cortex, and frontal cortex RNA data. D RPCD Risk score ROC curve in ROSMAP human brain RNA-Seq data. E RPCD Risk score ROC curve in ADNI cerebrospinal fluid proteomic data and in ADNI whole blood genomic data. F RPCD risk score and ROC curves of common AD biomarkers in MSBB hippocampal parahippocampal proteomic data. G, H, I Correlation analysis between the expression of 19 key genes and CDR, Braak and PlaqueMean Volcano Plots. Horizontal coordinates indicate the magnitude of the correlation and vertical coordinates are − log10 (p-value). Red dots indicate positively correlated genes and blue dots indicate negatively correlated genes