Fig. 6

Effect of RPCD Risk score on other brain regions in AD patients. A Box plot of differences in Braak stages in the frontal pole, inferior frontal gyrus, and superior temporal gyrus between high and low risk groups. T-tests were used to test for changes in Braak between patients between high and low risk groups. p-value: * < 0.05; ** < 0.01; *** < 0.001; **** < 0.0001. B Box plot of differences in CDR score in the frontal pole, inferior frontal gyrus, and superior temporal gyrus between high and Low risk groups. T-tests were used to test for changes in CDR between patients between high and low risk groups. p-value: * < 0.05; ** < 0.01; *** < 0.001; **** < 0.0001. C Box plot of differences in PlaqueMean in the frontal pole, inferior frontal gyrus, and superior temporal gyrus between high and Low risk groups. T-tests were used to test for changes in PlaqueMean between patients between high and low risk groups. p-value: * < 0.05; ** < 0.01; *** < 0.001; **** < 0.0001. D Proportion of people with different APOE genotypes in each group in the frontal pole region, inferior frontal gyrus, and superior temporal gyrus