Fig. 3

Establishes and evaluates RPCD risk scores. A Veen plot: intersection of differentially expressed PCD genes and key module genes in RPCD clusters. B Visualization of LASSO regression model based on the intersected genes, the optimal λ is obtained when the partial likelihood of the deviation reaches the minimum value. C Delineation of the 19 key genes in PCD species after LASSO regression model screening. D Variation of RPCD risk score in different kinds of populations, including Control and AD, male and female, and four different kinds of APOE genotype populations. T-test was used to test the significance between Control and AD. p-value: * < 0.05; ** < 0.01; *** < 0.001; **** < 0.0001. E Linear regression analysis of the correlation between RPCD Risk score and PlaqueMean. F Changes in RPCD Risk score at different Braak stages. T-tests were used to test for changes in risk scores between patients with different Braak stages. p-value: * < 0.05; ** < 0.01; *** < 0.001; **** < 0.0001. G Variation of RPCD Risk score at different CDR scores. T-tests were used to test for changes in risk scores between patients with different CDR scores. p-value: * < 0.05; ** < 0.01; *** < 0.001; **** < 0.0001. H RPCD risk score and ROC analysis curves for 19 key genes. I Column line graph showing the importance of RPCD Risk score, Age, CDR and Braak on AD risk