Fig. 2

Patient clustering based on RPCD gene expression and co-expression network analysis. A The screening process for RNA-modification-associated PCD genes (By Figdraw). B Unsupervised consistent clustering based on RPCD Gene expression, when k = 2, MSBB parahippocampal gyrus cohort patients were divided into two Clusters. C Comparison of clinically relevant information between the two RPCD Cluster and Control groups, including age, CDR, Braak and PlaqueMean. T-test was used to test the significance of changes between two clusters. p-value: * < 0.05; ** < 0.01; *** < 0.001; **** < 0.0001. D Differential expression of PCD genes in two comparisons between RPCD Cluster A, RPCD Cluster B and Control groups. E Dot plot of top10 GO terms for differentially expressed genes between RPCD cluster A and B. F Enrichment analysis results of differential genes on SynGO between RPCD cluster A and B. G Heatmap of correlation between gene co-expression network modules and RPCD clusters with clinically relevant information. Numbers in parentheses are p-values and numbers outside parentheses indicate correlations. H Dot plot of top10 GO terms for green module hub gene. I Dot plot of top10 GO terms for the blue module hub gene