Fig. 4

Summary of transcriptome-wide MR and Bayesian colocalization analysis results of five causal protein-coding genes. The MR estimates and P values evaluated by Wald ratio, IVW, and weighted median methods for five putative causal protein-coding genes across different tissues are summarized in the table, as well as the posterior probability of hypothesis 4 of Bayesian colocalization analysis. The ORs with 95%CI for a one standard deviation change of genetically predicted gene expression on AD risk are presented, along with corresponding forest plots. In the forest plot, the length of the horizontal line represents the CI and the box at the center of each horizontal line represents the OR. Color differences represent different stages. Color differences represent different tissue types. Red, blood; Blue, cortex; Orange, cerebellum; Green, hippocampus; Purple, basal ganglia; Light blue, spinal cord. IVW, inverse-variance weighted; OR, odds ratio; CI, confidential interval; Pval, P value; PP.H4, the posterior probability of hypothesis 4