Fig. 2
From: Important regulatory role of mitophagy in diabetic microvascular complications
Hyperglycemia induces dysregulation of mitophagy, leading to increased ROS production, NLRP3 inflammasome activation, increased inflammatory response, increased apoptosis, cellular iron death, accelerated cellular senescence, oxidative stress, decreased mitochondrial biogenesis, and ultimately aggravation of diabetic microvascular complications