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Table 1 Mediation MR analysis of SLDCGs influencing immune downstream mechanisms in NSCLC

From: Multidimensional bioinformatics perspective on smoking-linked driver genes and immune regulatory mechanisms in non-small cell lung cancer

Effect Type

HLA DR on B cells

(Treg)

CD8 on CD39 + CD8br

(TBNK)

β₃a

−0. 1179

β₁b

−0. 223,874,915

0. 182,144,243

β₂c

0. 142,144,391

−0. 180,979,521

Mediation Effect β (95% CI)d

−0. 032 (−0. 057,−0. 007)

−0. 0330 (−0. 063,−0. 003)

Mediated Proportion (%)e

21. 25%

21. 85%

P_valuef

0. 012

0. 031

Total Effectg

−0. 1497

−0. 1509

  1. a: β₃ = The causal effect of HLA-J on NSCLC
  2. b: β₁= The causal effect of HLA-J on HLA-DR expression on B cells; The causal effect of HLA-J on CD8 + CD39 + CD8br cells
  3. c: β₂ = The causal effect of HLA-DR expression on B cells on NSCLC; The causal effect of CD8 + CD39 + CD8br cells on NSCLC
  4. d: Mediation effect = The indirect causal effect of SLDCGs on NSCLC through immune cells, represented by the product of β₁ and β₂
  5. e: The mediated proportion = The proportion of the indirect effect relative to the total effect, calculated as the ratio of indirect effect / total effect, [β₁×β₂/ (β₃+β₁×β₂)]
  6. f: P_value = The significance of the indirect effect, with P < 0. 05 supporting the alternative hypothesis (presence of mediation effect)
  7. g: Total Effect= (β₃ + β₁ × β₂), the sum of the direct and indirect effects
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Journal of Translational Medicine

ISSN: 1479-5876

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