Fig. 6

Immune Cell Infiltration Analysis and Correlation Study of PRMT7 and HLA-J Genes. (a-b) Box plots comparing the immune cell enrichment levels between high and low expression groups of PRMT7 (a) and HLA-J (b). Each box plot represents the immune cell infiltration scores for the high expression group (red) and low expression group (blue). The middle line indicates the median, and the upper and lower box boundaries represent the upper and lower quartiles. (c-d) Scatter plots showing the correlation between PRMT7 (c) and HLA-J (d) gene expression and immune cell infiltration levels. Each point represents an immune cell type, with the point size indicating the significance of the correlation (-log10 of P value). The color of the points represents the direction and strength of the correlation: red indicates a positive correlation, and blue indicates a negative correlation. The intensity of the color reflects the strength of the correlation (the higher the absolute value, the darker the color). The x-axis represents the correlation coefficient. (e) Immune Correlation Heatmap: Each small square represents the correlation coefficient between molecules and cells. Darker colors indicate stronger correlations between the variables. Significance levels are indicated as * (P < 0. 05), ** (P < 0. 01), *** (P < 0. 001). (f) t-SNE plot showing the distribution of major cell types in the single-cell RNA sequencing data. Different colors represent the six major cell subpopulations. (g) t-SNE plot showing the expression distribution of the HLA-J gene in single cells. The bar graph quantifies the average expression levels of HLA-J in different cell subpopulations. (h) t-SNE plot showing the expression distribution of the PRMT7 gene in single cells. The color gradient from purple (low expression) to yellow (high expression) represents the relative expression levels of the gene. The bar graph quantifies the average expression levels of PRMT7 in different cell subpopulations