Fig. 5

Analysis of SLDCGs and Molecular Docking Results. (a) GO Enrichment Analysis of SLDCGs: Includes Biological Process (BP), Cellular Component (CC), and Molecular Function (MF). In the bubble chart, the size of each bubble represents the number of genes associated with each GO term. Larger bubbles indicate a greater number of genes enriched in the term, suggesting a closer relationship with the study objectives. The color of the bubbles reflects the significance level, with darker blue indicating a higher likelihood of statistical significance (smaller P value). (b) PPI Network of PRMT7: The color and thickness of the lines represent the combined_score values of the interactions (ranging from 0. 5 to 0. 9). (c) ROC Curve Analysis for HLA-J and PRMT7 Genes: The AUC value ranges from 0. 5 to 1, where a higher AUC value closer to 1 indicates greater diagnostic ability to distinguish between the normal and tumor groups. (d) Visualization heatmap of binding energy absolute values and hydrogen bond counts for molecular docking. (e) Docking results of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone with HLA-J protein. (f) Docking results of 4-Aminobiphenyl with HLA-J protein. (g) Docking results of Acrolein with HLA-J protein. (h) Docking results of N’-Nitrosonornicotine with HLA-J protein. (i) Docking results of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone with PRMT7 protein. (j) Docking results of 4-Aminobiphenyl with PRMT7 protein. (k) Docking results of Acrolein with PRMT7 protein. (l) Docking results of N’-Nitrosonornicotine with PRMT7 protein