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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Ferrostatin-1 reduces the inflammatory response of rheumatoid arthritis by decreasing the antigen presenting function of fibroblast-like synoviocytes

Fig. 6

Mechanism model of antigen-presenting effect of RA-FLSs induced by ferroptosis

The high level of ferroptosis in RA-FLSs causes the increase of intracellular PAD4 enzyme and citrullinated protein, which promote the function of endogenous antigen presenting and the aggregation of inflammatory factors. Ferrostatin-1 can inhibit the above reaction to achieve the therapeutic effect of RA

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Journal of Translational Medicine

ISSN: 1479-5876

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