Fig. 4

Effects of ferroptosis on joint inflammation and bone destruction in CIA mice

(a) illustration of CIA mouse model therapy in vivo; (b) Representative photography of the hind limb from mice taken on day 22, day 28 and day 35; (C) Arthritis score and paw thickness evaluated from day 20 to day 35; (d) Representative micro-computed tomography (micro-CT) images; NC = normal control. PBS = CIA mice group; Erastin = CIA mice treated with erastin group. Fer-1 = CIA mice treated with fer-1 group. Erastin + GSK484 = CIA mice treated with erastin and GSK484 group. Data are expressed as mean ± S.D. For statistical analysis, one-way ANOVA followed by Dunnett’s method for multiple comparisons. *P < 0.05; **P < 0.01, ***P < 0.001,****P < 0.0001