Fig. 6

Association between HNSC cell states, ecotypes, and chemotherapy response A Associations between the 66 cell states, the ecotypes identified in this study, pan-cancer ecotypes, and chemotherapy response were examined. B Correlation between E1 ecotype abundance and chemotherapy sensitivity in the Xiangya and TCGA chemotherapy cohorts. C Correlation between fibroblast (S02) abundance and chemotherapy sensitivity in the Xiangya and TCGA chemotherapy cohorts. D Representative multicolor immunofluorescence images showcasing varying abundances of ACTA2 + fibroblasts in the TMA chemotherapy cohorts. E Correlation between ACTA2 + fibroblast abundance and chemotherapy sensitivity in TMA chemotherapy cohorts