Repurposing the anti-parasitic agent pentamidine for cancer therapy; a novel approach with promising anti-tumor properties

Table 2 The list of studies employing PTM with other anti-cancer modalities in the form of combination therapy

Combination	Cancer type	Subject	Advantage	Reference
Radiotherapy + gold nanoparticles + PTM	Triple Negative Breast Cancer	MDA-MB-231 and MDA-MB-436 cells	Increase in cytotoxicity, radiosensitization, and number of residual DNA double-strand breaks compared to radiation alone	[21]
Chlorpromazine + PTM	lung cancer and colon cancer	Severe combined immunodeficient Hsd:ICR mice bearing A549 or HCT116 cells	Inhibiting tumor growth more effectively than either PTM or chlorpromazine alone	[22]
LY294002 + PTM	Endometrial cancer	Ishikawa cells	Increased inhibition of cell viability and the protein expression of p-AKT	[43]
FOLFIRINOX + PTM	Pancreatic cancer	Athymic nude mice bearing S2-013 and HPAF-II cells	Improved efficacy of FOLFIRINOX, a significant decrease in the tumor growth kinetics, reduced tumor volume and weight parameters	[18]

ISSN: 1479-5876