Fig. 4

In vitro and in vivo experiments demonstrated the effect of MCT4 expression on gastric cancer cells. A The cell migration ability of AGS gastric cancer cell lines with low MCT4 and normal AGS gastric cancer cell lines was measured using small interfering RNA. B, C Cell migration ability of AGS gastric cancer cell lines with low MCT4 and normal AGS gastric cancer cell lines knocked with small interfering RNA. D–F CCK8 proliferation capacity of HGC-27 cells after MCT4 knockdown. G Cell migration of HGC-27 cells after MCT4 knockout. H Cell scratch assay of HGC-27 cells after MCT4 knockout. I Statistical map of tumor weight of HGC-27 cells after MCT4 knockout. There was no significant difference in tumor weight in situ between the two groups after MCT4 knockout. J VB124 interfered with the expression of MCT4 in HGC-27 cells for experimental tumor transplantation in vivo. There was no significant difference in tumor size in situ after VB124 interfered with MCT4 expression. K HGC-27 cells after MCT4 knockout were used to model the liver of mice implanted with splenic tumor liver metastasis. After MCT4 knockout, the number of liver metastases in KO group decreased significantly