Table 1 Wnt path research node

[75]

Int1

Int1 gene was cloned from mouse breast cancer cells, and it was found that Int1 could promote the development of cancer.

[76]

Dint-1

Dint-1, a homologue of int-1, was isolated from Drosophila melanogaster by cross hybridization. And Dint-1/wingless plays an important role as a signal of intercellular communication.

[77]

catenin

The catenin α, β and γ are named.

[78]

β- catenin

β -catenin was found in all the embryonic stages of Xenopus laevis, and was related to C- cadherin.

[79]

GSK3β

GSK3β can bind to β -catenin and Drosophila adenomatous polyposis coli gene (APC).

[80]

TCF-1/Lef-1

TCF-1/Lef-1 can bind to β -catenin and can bind to target DNA as a complex.

[81]

Frizzled

The curled protein was identified as Wnt receptor and the function of Dishevelled was discussed.

[82]

GBP

GBP (a parent Xgsk-3 binding protein) inhibits the phosphorylation of Xgsk-3 in vivo and is an inhibitor of GSK-3.

[83]

Dsh

Dsh activates JNK pathway; Wnt/Frizzled signaling pathway uses multiple intracellular signal cascades.

[84]

TCF

CBP inhibits TCF.

[85]

Axin

Axin protein family is very important in Wnt/Wingless signal of Drosophila.

[86]

LRP6

LRP6 plays a wide role in the transduction of several Wnt signals in mammals.

[87]

Wnt/Ca2+

Wnt/Ca2 + pathway activates NF-AT and mediates ventral signals of Xenopus laevis embryos.

[88]

Notch

Wnt and Notch cascade

[89]

Hedgehog

Shaggy/GSK3 is also a negative regulator in Hedgehog (Hh) pathway.

[90]

c-Jun、 TCF4

Phosphorylation-dependent interaction between c-Jun and TCF4 regulates intestinal tumorigenesis by integrating JNK and APC/β-catenin.

[91]

WTX

WTX promotes ubiquitination and degradation of β-catenin, thus antagonizing Wnt/β- catenin signal transduction.

[92]

Wnt

The axial mode of Wnt signal transduction is earlier than the evolution of bilaterally symmetrical animals.

[93]

TAZ

A large part of Wnt transcription reaction is mediated by TAZ.

[94]

YAP

YAP inhibits Wnt signal by limiting DVL nuclear translocation during regenerative growth.

[95]

YAP/TAZ

The release of YAP/TAZ in the complex contributes to Wnt/β-catenin signal transduction.

[96]

DVL

As a WNT signaling pathway, DVL promotes complex assembly and downstream signal transduction, and also serves as a linker to recruit ZNRF3 and RNF43 to WNT co-receptors to promote their degradation and down-regulation.

[97]

Lgr5

Wnt/β-catenin signaling realizes bile duct regeneration by regulating the expression of Lgr5 gene in ductal response cells (DRCs) located near peribiliary glands.

[72]

TMEM9

Transmembrane protein 9 (TMEM9) is a Wnt signal amplifier, and Tmem9 knockout will damage liver regeneration.

[98]

Wnt2

C-kit + SECs promotes liver partition and regeneration through Wnt2, and is regulated by Notch signal transduction.

[99]

TCF1 、LEF1

TCF1 and its homologue LEF1 have historically been called effective transcription factors downstream of wnt signaling pathway, which are essential for early T cell development.

[100]

Wnt/β-catenin

Wnt/β-catenin pathway is activated in the early stage of LR, and the conditional loss of β-catenin liver cells will delay LR.

[101]

Wnt/β-catenin

Activation of Wnt/β-catenin signal transduction is the main mitogenic clue of adult primary human hepatocytes.

[102]

Wnt

Cell maturation is mediated by the activation of NF-κ в and the inhibition of Wnt signal respectively.

[103]

Cachd1

Cachd1 can bind to both Lrp6 and Wnt co-receptors of Frizzled family.