Fig. 7

Mechanistic model of X-ray irradiation-induced tumor angiogenesis through PRDM10-DT/miR-663a/TGF-β1 axis that activated by SP1 in lung adenocarcinoma cells. Radiation activates SP1 binding to PRDM10-DT promoter region and enhances the transcription of PRDM10-DT. Up-regulated PRDM10-DT competitively binds miR-663a and then promotes TGF-β1 and VEGF expression and facilitates tumor angiogenesis