Table 2 Pathway enrichment analysis of global transcripts (p-value < 0.01), mitochondrial-related transcript (p-value < 0.05), and DNA methylation (p-value < 0.01) that correlated with circulating serum IPA signal intensity
From: Indole-3-propionic acid promotes hepatic stellate cells inactivation
List | Number of genes | Pathway | Enriched genes | q-value | p-value |
|---|---|---|---|---|---|
Global | 268 | Apoptosis | BCL2L11, BIRC2,MAPK10 | 0.585 | 0.0089* |
Mitochondrial | 119 | Apoptosis | BCL2L1 | 0.0017* | 0.000010* |
BCL2L11, BOK, MAPK10 | |||||
Mitophagy | TNFRSF1A | 0.0095* | 0.00029* | ||
BCL2L1, JUN, MAPK10, | |||||
TNF signaling pathway | MFN1, TBC1D15, | 0.0017* | 0.000006* | ||
AKT1, DNM1L, JUN, MAP2K1, MAPK10, MAPK14, RIPK3, TNFRSF1A | |||||
CpGs | 4350 | Longevity | RPS6KB1, AKT1S1, HSPA1L, SOD1, AKT1, PIK3CD, ADCY4, ADCY9 | 0.224 | 0.006* |
Overlapped Global + Mitochondrial + CpGs | 56 | Apoptosis | BCL2L1, BCL2L11, MAPK10 | 0.0185* | 0.00029* |