Fig. 1

Overlap analysis of global transcripts, mitochondrial-related transcripts, and DNA methylation in the human liver associated with serum IPA levels. A The Venn diagram representing 268 global transcripts, 119 mitochondrial-related transcripts, and DNA methylation of transcripts that map to 3092 CpGs sites correlated with serum IPA levels (p-value < 0.01 for global and DNA methylation, p-value < 0.05 for mitochondrial-related transcripts). The main overlapped transcripts are shown in the middle (AKT1 and YKT6). B Interaction map of 13 genes with the highest score interactions with other genes (0.900) using the StringDB online tool from the 56 overlapped genes (black lines area) that significantly associated with serum IPA levels. In green: genes that map to gene ontology (GO) cellular component: mitochondrion (GO:0005739). AKT1 is the protein that has more highest score interactions (0.900) with other proteins based on data support (based on text mining, experiments, databases, and co-expression). The network nodes represent proteins and the edges represent protein–protein associations