Fig. 7
From: Cancer ATF4-mediated CD58 endocytosis impairs anti-tumor immunity and immunotherapy
CD58 expression deficiency is related with diminished response to immunotherapy. a The correlation of the level of ATF4 or CD58 expression with the level of cytotoxic T cell (CTL) based on the Tumor Immune Dysfunction and Exclusion database. b CD58 and ATF4 expression level in in immunotherapy response (n = 2) and nonresponse (n = 6) human HCC tissues. c Kaplan–Meier plots showing the correlation between ATF4 expression levels and overall survival (OS) as well as progression-free survival (PFS) of melanoma patients receiving anti-PD-1 treatment from the Liu2019 cohort based on the Tumor Immune Dysfunction and Exclusion database. Statistical analysis performed using two-tailed t-test. ns for P>0.05, *for P < 0.05, **for P < 0.01, ***for P < 0.001, ****for P < 0.0001