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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: LncRNA PVT1 activated by TGF-β1/Smad3 facilitates proliferation and metastasis of hepatocellular carcinoma via upregulating Smad6 and NRG1

Fig. 1

PVT1 was highly expressed in HCC and up-regulated by TGF-β1. (A) The GEPIA database indicated the PVT1 expression in liver cancer and normal tissue. (B) The Kaplan-Meier Plotter platform assessed the overall survival (OS) in HCC patients. (C) qRT-PCR was carried out to assess the expression of PVT1 in hepatocytes and hepatoma cells. (D-G) qRT-PCR was carried out to assess the expression of PVT1 in Huh7, PLC/PRF/5, MHCC97H, and HCCLM3 cells after treatment with TGF-β1 (10 ng/mL) for 1 and 2 days. (H-K) qRT-PCR was carried out to assess the PVT1 expression after the treatment of SB431542 (5 µM). The data are expressed as the mean ± SD (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Journal of Translational Medicine

ISSN: 1479-5876

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