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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: HMGCL activates autophagy in osteosarcoma through β-HB mediated inhibition of the PI3K/AKT/mTOR signaling pathway

Fig. 1

HMGCL expression is down-regulated in osteosarcoma, and its low level is associated with poor patient prognosis. (A) Expression patterns of HMGCL in various tumors and normal tissues based on the TIMER database. (B) mRNA levels of HMGCL in osteosarcoma tissues and adjacent tissues of clinical patients. (C) Protein levels of HMGCL in osteosarcoma tissues and adjacent tissues of clinical patients. (D) Quantitative analysis of HMGCL protein expression. (E-G) Protein and mRNA expression levels of HMGCL in human osteoblasts and osteosarcoma cells. (H-I) Kaplan-Meier survival analysis of patients with high or low HMGCL expression in TCGA and GEO databases. (J-K) Univariate and multivariate COX analysis was performed to evaluate the prognostic ability of HMGCL. * P < 0.05, *** P < 0.001

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Journal of Translational Medicine

ISSN: 1479-5876

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