Fig. 4
Internal irradiation changes the metabolites and mRNA profiles of mouse colon tissues. (A) Venn diagram showing common and specific metabolites detected LC-MS in colon tissue of 0.5 mCi, 1.0 mCi irradiation and control group of mice. (B) Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of the dysregulated metabolites in colon tissue of irradiated mice. 9 metabolic pathways were found to be enriched by differential metabolites in the 0.5 mCi irradiated group. (C) 14 metabolic pathways were found to be enriched by differential metabolites in the 1.0 mCi irradiated group. (D) Heatmap of differentially expressed mRNAs in 0.5 mCi, 1.0 mCi irradiated and control group. (E) Veen diagrams showing common and specific mRNAs detected by RNA-Seq. (F) The volcano plot of mRNAs between 0.5 mCi irradiated group and control group in colon tissue. (G) The volcano plot of mRNAs between 1.0 mCi irradiated group and control group in colon tissue. (H) and (I) GO analysis of the target genes of differentially mRNAs in 0.5 mCi Vs control group and 1.0 mCi Vs control group. (J) Specific data display of common differential mRNA in 0.5 mCi Vs control group and 0.5 mCi Vs control group. (K)-(M). GO analysis of the mRNAs that are differentially expressed in both treatment groups (0.5mCi and 1mCi) as compared to the control group in molecular function, biological process and cellular component