Fig. 1

Internal irradiation induces the death and intestinal injury in mice. (A) Schematic showing internal irradiation model in C57BL mice and the procedures for 16sRNA sequencing, metabolic analysis (LC-MS and GC-MS) and transcriptome sequencing. (B) Dose estimation after gavage of different doses of Y90 nuclide. (C) Kaplan-Meier analysis of male mice treated with radionuclides of different dose (0, 0.2, 0.5, 1.0 or 5.0 mCi). (D) Representative H&E-stained sections of the small intestines. Scale bar = 500 μm. (E) The height of small intestine villus and the number of crypts pre mm in different group. (F) and (G) Intestines of mice in different Y90 gavage groups. The data are shown as the mean ± SEM for three independent experiments. *P < 0.05; **P < 0.01