Fig. 6

Cell communication between VEGFA + CAF and CapECs contribute to angiogenesis.in HCC. A UMAP plot demonstrating subpopulations of endothelial cells. B Heatmaps illustrating the top five most highly expressed genes in the various subpopulations of endothelial cells. C OR plots demonstrating the tissue distribution preferences of different fibroblasts as well as endothelial cell subpopulations. D VEGFA + CAF and CapEC scores, colocalized spots, and abundance distribution in the HCCT_5_3 sample. E VEGFA + CAF and CapEC scores, colocalized spots, and abundance distribution in the HCCT_5_2 sample. F Scatter plots demonstrating the activity of all pathways, as well as the VEGF pathway alone. G Heatmap demonstrating the strength of outgoing and incoming interactions of VEGF pathways between endothelial cells and fibroblast subpopulations