Fig. 5

VEGFA + CAF was associated with poor prognosis. A UMAP plot demonstrating the distribution of Scisso + as well as Scissor − cells among the three fibroblasts. B Bar graph demonstrating the percentage of Scisso + cells in the fibroblast subpopulation. C Kaplan–Meier survival curve demonstrating the differences in OS as well as RFS in patients with different Scisso + as well as Scissor − cell abundance. D Demonstration of survival-independent cells, Scisso + as well as Scissor − cell subpopulations of highly and lowly expressed genes. E Forest plot demonstrating the relationship between the three fibroblast abundances and patient OS (in TCGA-LIHC). F Kaplan–Meier survival curve demonstrating the differences in OS in patients with different VEGFA + CAF abundances. G Kaplan–Meier survival curve demonstrating the differences in OS in patients with different VEGFA + CAF abundances in the two external validation sets, VEGFA + CAF was not only associated with poorer OS but also poorer RFS