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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Integration of single-cell and spatial transcriptomics reveals fibroblast subtypes in hepatocellular carcinoma: spatial distribution, differentiation trajectories, and therapeutic potential

Fig. 2

Subpopulation and functional enrichment analysis of fibroblasts. A UMAP shows that fibroblasts can be clustered into three subpopulations. B UMAP plot showing the expression of three typical genes (MMP11/HLA-DRB1/VEGFA) in three fibroblast subpopulations. C Heatmap showing top 5 highly expressed genes in each subpopulation of fibroblasts. D–F Bar plot showing top 5 terms or pathways significantly enriched for HLA-DRB1 + CAF, MMP11 + CAF, VEGFA + CAF. G Heatmap showing the different subtypes of fibroblasts' progeny pathway scores. H Box line plots showing the scores of basement membrane, interstitial collagen, collagen, ECM glycoproteins, and proteoglycans in comparison for three subpopulations of fibroblasts. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001

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Journal of Translational Medicine

ISSN: 1479-5876

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