Fig. 1

Isolation of fibroblasts in HCC. A UMAP shows cell clustering of cell types in the discovery cohort. B UMAP plot showing highly expressed genes in cell types. C Scatterplot showing the classification of fibroblasts and mural cells based on canonical gene markers. D Bar graph showing the percentage of fibroblasts/mural cells as well as undetermined cells in each mesenchymal subpopulation based on the classification results. E UMAP plot showing the results of fibroblasts and mural cells demarcation in the discovery cohort using the consensus gene signature