Fig. 5

Cell typing and cellular neighbourhoods across response groups (CR (A), PR (B), SD (C), PD (D)). Comparison of cellular neighbourhoods with and without including isPLA⁺ clusters showing a different isPLA⁺ neighbourhoods distribution across different response groups. E) The cell typing heatmap shows the expression markers’ intensity vs. proposed cell types. F, G) Cell types were clustered into unsupervised cellular neighbourhoods according to their nearest neighbours. The heatmap shows an abundance of cell types in each neighbourhood with and without including isPLA positivity