Fig. 5

Different states of endothelial cells in the PAN and MVP regions. A, B UMAP of GBM spatial transcriptome data. Composition of different kinds of cells in PAN and MVP regions was shown. C, D UMAP plot of the endothelial cells in glioma. UMAP plot colored based on the expression of PAN and MVP signatures. E Heatmap showing top 10 differentially expressed genes in PAN and MVP associated endothelial cells. F Heatmap showing top 10 enriched GO terms in different endothelial cells based on differentially expressed genes between PAN (748) and MVP (746)