Fig. 2

Identification and characterization of metabolic subtypes in HTG (A) Principal Component Analysis (PCA) plot showing the separation of three metabolic clusters identified based on the results of K-means unsupervised clustering analysis (B) Proportional distribution of major metabolite classes across the three clusters, including fatty acyls, glycerolipids, glycerophospholipids, and sphingolipids (C) Heatmap illustrating the abundance profiles of metabolites within each cluster, showing distinct metabolic patterns