MT2A promotes angiogenesis in chronically ischemic brains through a copper–mitochondria regulatory mechanism

Table 4 Subgrouping of SD rats for the animal experiments with IVLI

Groups (n = 8)	Procedures
Control group		2VO + EMS
CPO group		2VO + EMS with ES treatment
CPO^MT2A+ NC group		Transfected with LV-NC after 2VO + EMS with ES treatment, then transfected with LV-NC
CPO^MT2A+ group		2VO + EMS with ES treatment, then transfected with LV-MT2A
CPO^MT2A− NC group		2VO + EMS with ES treatment, then transfected with shRNA NC
CPO^MT2A− group		2VO + EMS with ES treatment, then transfected with shRNA-MT2A

2VO: 2-vessel occlusion; ES: elesclomol; EMS: encephalo-myo-synangiosis; CPO: copper overload; MT2A: metallothionein 2 A; NC: negative control; IVLI: intraventricular lentivirus injection

ISSN: 1479-5876