Fig. 1

Experimental schedule. (A) Schedule used for observing the effects of EMS on EC proliferation, CBP and cognitive function in 2VO + EMS rats. (B) Schedule used for observing the effects of elesclomol on EC proliferation, CBP and cognitive function in 2VO + EMS rats. (C) Schedule used for observing the effects of MT2A on EC proliferation, CBP and cognitive function in 2VO + EMS rats during CPO. EMS: encephalo-myo-synangiosis; EC: endothelial cell; CBP: cerebral blood perfusion; CPO: copper overload; LDF: laser Doppler flowmetry; CCA: common carotid artery; MWM: Morris water maze; IF: immunofluorescence; WB: western blotting; TEM: transmission electron microscopy; IVLI: intraventricular lentivirus injection