Fig. 8

The impact of epigenetic alterations on cell‒cell communication in ESCC. a, b CellChat heatmap showing the initiators (a) and receivers (b) of epithelial, fibroblast, macrophage, and T-cell subsets in tumor (right) and normal (left) tissues, as well as the intensity of action. c Circle plot showing the interactions among the TWEAK signaling pathway in subsets of epithelial cells, fibroblasts, macrophages, and T-cells in peritumoral (upper) and tumor (lower) tissues. d Violin plots showing the expression levels of TWEAK pathway ligands and receptors in different epithelial, fibroblast, macrophage, and T-cell subsets in tumors and peritumor tissues. e UMAP plot colored according to log-normalized gene scores showing the accessibility of cis-regulatory elements linked to TNFRSF12A and TNFSF12 in macrophages (left), epithelial cells (middle) and fibroblasts (right)