Table 1 Paper characteristics
From: Detection of breast cancer lesions using APT weighted MRI: a systematic review
Author Country, Year | Design | Patients (N) | Benign/Malignant Lesions (N) | Main Findings |
|---|---|---|---|---|
Zhuang L China, 2023 [26] | P | 40 | 14/28 | - Malignant lesions had a significantly higher APT than benign lesions - MTRasym (APT) had similar efficiency to TIC (DCE) |
Kamitani T Japan, 2023 [27] | R | 66 | 0/66 | - Triple negative tumors had higher signal intensity - Positive correlation between Ki67 and signal intensity |
Liu Z China, 2023 [28] | P | 84 | 16/68 | - Malignant lesions had a significantly higher APT than benign lesions - Stage 1(TNM grading) showed lower APTw signals stage 2 or 3 - Positive correlation between Ki67 and signal intensity |
Meng N-1 China, 2021 [29] | R | 133 | 59/76 | - Benign lesions had a significantly higher APT than malignant lesions - Positive correlation between histologic grade and signal intensity - DKI was superior to APT |
Zhang N-1 China, 2022 [30] | P | 56 | 15/41 | - Malignant lesions had a significantly higher APT than benign lesions - Negative correlation between ER and signal intensity - APT had similar efficacy to DCE and was superior to DWI |
Zhang S USA, 2021 [31] | P | 51 | 0/51 | - APT decreased in both responders and nonresponders of NAC, but it could not differentiate between the two groups |
Li Y China, 2024 [32] | P | 78 | 43/37 | - Benign lesions had a significantly higher APT than malignant lesions - Positive correlation between histologic grade and signal intensity - APT had similar efficacy to DCE |
Yu T China, 2024 [33] | P | 52 | 8/44 | - Malignant lesions had a significantly higher APT than benign lesions - APT had similar efficacy to DKI and IVIM |
Zhang N-2 China, 2024 [34] | P | 50 | 0/50 | - APT signal change in NAC responders was greater than nonresponders |
Meng N-2 China, 2020 [35] | R | 121 | 59/62 | - Benign lesions had a significantly higher APT than malignant lesions - Positive correlation between histologic grade and signal intensity - APT had similar efficacy to IVIM |
Dula AN USA, 2013 [36] | CS | 3 | 0/3 | - Case series of 3 NAC patients (2 responders/1 nonresponder) |
Loi L Germany, 2020 [37] | P | 10 | 0/10 | - Malignant lesions had significantly higher APT than healthy tissue (no benign lesions in this study) - Moderate positive correlation between Ki67 and signal intensity |
Krikken E-1 Netherlands, 2018 [38] | P | 9 | 0/10 | - Significant signal change in responders before and after NAC - Could not distinguish responder from nonresponder change in NAC |
Krikken E-2 Netherlands, 2019 [39] | P | 22 | 0/22 | - Paper looked at the pH relationship to APT. Found a decrease in pH led to increase in APT |