Fig. 8

IFN-γ contributed to the reduced expression of AHRR. (A) Inflammatory cytokines expression in ileal tissues of Mpj and Lpr mice analyzed by qPCR. (B) AHRR and CYP1B1 expression in Jurakt cells induced by different concentrations of IFN-γ. AHRR, Aryl Hydrocarbon Receptor Repressor. (C) Representative flow cytometry result and quantification of C11 BODIPY staining in Jurkat cells induced by different concentrations of IFN-γ. Statistical significance in (A) was determined by student’s t-test and (B and C) was determined by a one-way ANOVA test with Dunnett’s multiple comparisons test. Each dot denotes an individual sample. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001