Fig. 5

Significantly modified signaling pathways and ligand-receptor analysis reveal the restructuring of the intestinal interactome network in lupus mice. (A) Circle plot of the TGFb, PARs, CXCL, and CCL signaling pathways from Cellchat. Receptor-ligand edges were labeled based on communication probability. TGFb, transforming growth factor β; PARs, protease-activated receptors; CXCL, C-X-C motif ligand; CCL, CC chemokine ligand. (B) Dot plots showing the expression of ligands (left) and receptors (right) in intestinal cells of Mpj and Lpr mice, with dominant exhibition on chemokines. Color saturation denotes the strength of gene expression on average, while the size of dots corresponds to the proportion of each cell cluster expressing the gene