Fig. 3

Performance of the TADI model. A C-index values of TADI and pathologically based risk parameters in the training and validation sets. B t-AUC (left) and C-index (right) for the TADI model, the anatomy-based parameters model and the anatomy-based parameters plus the TADI model. The left side of each violin plot represents the data in the training set and the right represents the data in the validation set. C–D Calibration plot of observed versus predicted 1-year, 3-year and 5-year time to recurrence for the TADI model in the training set and validation set. TADI, Tumor Aggression-Defense Index; RIS, regulatory-Immunoscore, TLS, tertiary lymphoid structures; SFL-TLS, secondary follicle-like stage TLS; t-AUC, the time-dependent area under the curve