Fig. 8
The MIR4435-2HG/miR-1252-5p/STAT1 pathway is critical for pancreatic cancer stemness in vivo. (A) Representative images of subcutaneous xenografts from BxPC-3 cells with MIR4435-2HG knockdown (n=6). (B) Body weight of mice bearing subcutaneous xenografts. (C) Tumor volume and (D) tumor weight of xenografts. (E) Flow cytometry plots showing the percentage of CD44+ cells in MIR4435-2HG knockdown xenograft tumors. (F) Representative immunohistochemistry (IHC) images of Ki67, KLF4, CD44, and phosphorylated STAT1 (p-STAT1) in xenograft tumor tissues. *p<0.05, **p<0.01, ***p<0.001