Fig. 7

Schematic diagram of this study. In sepsis, the downregulation of the transcription factor BRD4 in VECs leads to a decrease in BCL-xL levels, resulting in mitochondrial dysfunction and apoptosis, thereby causing coagulation disorders. PTL upregulates the expression of BCL-xL by enhancing BRD4 expression, inhibiting mitochondrial-mediated apoptosis in VECs, and ultimately ameliorating coagulation dysfunction in sepsis. Moreover, N-PTL, synthesized through nanotechnology, offers enhanced protective effects on VECs and coagulation function