Fig. 2
From: Multi-omics analysis reveals novel causal pathways in psoriasis pathogenesis
Multi-omics analysis of methylation quantitative trait loci (mQTLs) and their association with psoriasis. A, B Circular plot showing mQTLs correlated with psoriasis risk. The outer ring shows individual mQTL sites. Inner rings represent, from outermost to innermost: p-values (p_HEIDI), SMR statistics (p_SMR_bxy), and odds ratios (OR). Note the different OR scale between A and B. C Venn diagram showing the overlap of mQTLs between the discovery cohort (421 mQTLs) and the validation cohort (416 mQTLs). The intersection reveals 194 mQTLs common to both cohorts, demonstrating robust replication. D. Enrichment analysis of the 194 validated mQTLs. The y-axis lists significantly enriched biological processes, traits, or pathways. The x-axis shows the enrichment p-value. The size of dots represents the number of genes involved in each process (count), while the color indicates the significance level (adjusted p-value). Key enriched terms include aging, smoking, and various autoimmune and inflammatory conditions