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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Ferroptosis-related genes participate in the microglia-induced neuroinflammation of spinal cord injury via NF-κB signaling: evidence from integrated single-cell and spatial transcriptomic analysis

Fig. 4

Construction of protein–protein interaction (PPI) and miRNA-DEFIRG-transcription factor (TF) regulatory network. a Venn diagram showing the 2 DEFIRGs obtained by intersecting; PPI network of DEFIRGs was constructed based on the STRING database. b Gene ontology (GO) enrichment analysis of hub genes from cluster 1 in biological processes, cellular components, and molecular functions. c GO enrichment analysis of hub genes from cluster 2 in biological processes, cellular components, and molecular functions. d MiRNA-mRNA-TF regulatory network of DEFIRGs was constructed based on the Networkanalyst database. e Connectivity Map (CMAP) analysis identified the top 10 most specific small-molecular inhibitors for DEFIRGs. f Mode of action (MoA) and structural formula of the top 3 most specific drugs (benzanthrone, piperacetazine, and westcort). g ChIP-seq validation demonstrated the binding relationships between TFs and DEFIRGs in the regulatory network

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Journal of Translational Medicine

ISSN: 1479-5876

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