Fig. 3
From: Metabolic state uncovers prognosis insights of esophageal squamous cell carcinoma patients
Top expressed genes and pathways in each metabolic state. (A) Dot plot showing expression of canonical marker genes for 16 metabolic states. (B) Heatmap of top metabolic gene expressions for each metabolic state. Differentially expressed genes were identified using the FindAllMarkers function of the Seurat package. Only the top 5 differentially expressed metabolic genes were included. (C-D) The top five enriched pathways (C) and metabolic pathways (D) for each metabolic state. Adjusted p-values (p.adjust) were calculated using the compareCluster function of the clusterProfiler package, applying the Benjamini-Hochberg method. Over-representation analysis (ORA) of differentially expressed genes for each metabolic state was performed using genes with avg_log2FC > 0.8. The top 5 pathways for each metabolic state were ranked by p.adjust and clustered