Fig. 1

Effects of losartan on kidney function and structure in diabetic mice induced by HFD/STZ. A: Losartan impacted body weight in DKD mice. B: Blood glucose level was compared between subsets. C: Serum creatinine levels. D: Urine ACRs. E: Mice and renal illustrations of three subsets. Data are mean ± SE, *P < 0.05 vs. CON subset; # P < 0.05 vs. DKD subset. n = 8. F and G: Tubules and glomeruli in DKD subset deformed in PAS staining images (upper) and under electron microscope (lower) compared to CON subset. LST administration significantly improved these changes. H and I: Quantitative analysis of glomeruli and tubule damage scores across three subsets. Results are depicted as mean ± SE, *P < 0.05, vs. CON subset; # P < 0.05, vs. DKD subset. n = 8